Here's a collection of some of my favorite spots to check out what's cool in design, etc, or which I simply find inspiring:

Matt Stuart Photography - a wonderfully tongue-in-cheek photojournalist collection

Banksy - world's most clever graffitist

Threadless T-Shirts - cool user-submitted gaphic tees

DeviantArt - artists' community of portfolio sharing

CoolBloom - new & hot architecture

Globally Gorgeous - everything ecological in design & home

Post Secret - poignant, artful postcards sharing anonymous deep dark secrets

Dezeen - what's happening in architecture-land

Bustler - see description above

InHabitat - awesome sustainable ideas in a variety of fields

TED - every topic you can't even imagine ... a collection of jaw dropping, inspiring, ingenius video presentations